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The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and which are structurally not associated to SET-domain proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a few proteins along with histones (see later); they need to subsequently be named protein lysine methyltransferases fairly than histone lysine methyltransferases. Methylation been found on a range of lysine residues in various histones: K4 (using the single-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular area of histone H4 2 and K26 of histone H1B 3 Several proteins accountable for the methylation of specific residues have been characterised, and all but one of these [incorporates](https://www.foxnews.com/search-results/search?q=incorporates) a SET area; they make up the SET-area protein methyltransferase family (Table 1 ). These tails are subject to several post-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).
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